KMID : 0882420110810060723
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Korean Journal of Medicine 2011 Volume.81 No. 6 p.723 ~ p.728
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Association of Exercise-Induced Asthma with Atopy in Adult Patients with Asthma-Like Symptoms
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Han Jin-Hyung
Kwon Byung-Woon Hyun Kyung-Hee Kim Yong-Hyun Lee Hyun-Suk Kim Do-Hyung Kim Youn-Seup Park Jae-Seuk Kim Kyung-Mook Jee Young-Koo
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Abstract
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Background/Aims: Atopy is closely related to asthma and is a risk factor for the development and exacerbation of asthma. The aim of this study was to evaluate the association between exercise-induced asthma (EIA) and atopy in adult patients with asthma-like symptoms.
Methods: Forty young male patients with asthma-like symptoms were enrolled. Skin prick, methacholine ronchial provocation, and exercise provocation tests were performed. Current and ex-smokers were excluded.
Results: Exercise provocation tests were positive in 21 patients (52.5%). Airway hyperresponsiveness (AHR) to methacholine (85.7% vs. 42.1%, p = 0.007) and atopy (85.7% vs. 47.4, p = 0.017) was found more frequently in patients with EIA than in those without EIA. EIA was significantly associated with atopy score (16.5 ¡¾ 3.0 vs. 6.5 ¡¾ 2.0, p = 0.011), atopy index (2.1 ¡¾ 0.3 vs. 1.0 ¡¾ 0.3, p = 0.004), and positive responses to Dermatophagoides pteronyssinus (76.2% vs. 42.1%, p = 0.028) and Dermatophagoides farinae (76.2% vs. 36.8%, p = 0.012), but not with positive responses to pollen allergens. AHR to methacholine (odds ratio [OR]: 14.3, 95% confidence interval [CI]: 1.86-109.4) and atopy (OR: 16.9, 95% CI: 2.04-140.74) were significant risk factors for EIA.
Conclusions: Atopy was a risk factor for EIA in young adult men, and sensitization to house dust mites was associated with EIA.
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KEYWORD
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Exercise-induced asthma, Atopy, Bronchial hyperreactivity
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